Granzyme-B Expression as a Predictor of Immune Surveillance (Correlation Study in Patient with Squamous Cell Carcinoma and Uterine Cervical Dysplasia)

Background: The most common histologic type of cervical cancer is squamous cell carcinoma (SCC), with the risk recurrence depending on immune surveillance granzyme-B markers, and tumor infiltrating lymphocytes (TIL) an immunological determinant associated a better prognosis. Granzyme-B produced by TIL. study was aimed to prove difference in expression SCC epithelial cells dysplasia precancerous lesions as predictor surveillance. Methods: Correlation analytic cross-sectional design paraffin block patients at Anatomical Pathology Laboratory, RSUP Dr. Kariadi, Semarang, during 2018 2019, using immunohistochemistry assays, assessed TIL activation. Results: Most cases were 40 years old, 50% stage IIIB, 20% final condition died observation 1 year after initial diagnosis made. uterine group expressed mean score 5.81±1.17 (p=0.001) dysplastic lesion 6.83±0.95 (p=022), Mann-Whitney test showed p value = 0.009, so that results are statistically significant. Conclusion: Expression higher than SCC.